KRTAP10-5

Across TCGA patient cohorts, KRTAP10-5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP10-5-associated genes across cancer lineages are NF-kB-p65_pS536, Notch1, and PEA-15_pS116. Each is linked with KRTAP10-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP10-5-to-partner and partner-to-KRTAP10-5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by KRTAP10-5-low versus KRTAP10-5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP10-5→partner) and Y-score (partner→KRTAP10-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF-kB-p65_pS536 →	-0.584	-3.000	.026	.037	3	1
UCEC	Notch1 →	+0.168	+3.000	.038	.037	3	1
UCEC	PEA-15_pS116 →	+0.664	+3.000	.001	.037	3	1
UCEC	ATM →	-1.151	-3.000	<.001	.037	3	1
UCEC	4E-BP1 →	+0.617	+2.837	<.001	.035	3	1
UCEC	DJ-1 →	+0.303	+2.820	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

NF-kB-p65_pS536 by KRTAP10-5 expression — UCEC

Explore this box plot interactively →