KRTAP10-11

Across TCGA patient cohorts, KRTAP10-11 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP10-11-associated genes across cancer lineages are VHL, ATM, and Bak. Each is linked with KRTAP10-11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP10-11-to-partner and partner-to-KRTAP10-11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by KRTAP10-11-low versus KRTAP10-11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP10-11→partner) and Y-score (partner→KRTAP10-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.713	-3.807	<.001	<.001	3	2
UCEC	ATM →	-0.567	-3.308	.003	.009	3	2
UCEC	Bak →	+0.248	+2.321	.019	.033	3	2
UCEC	c-Met_pY1235 →	+0.067	+1.594	.034	.042	3	2
UCEC	eIF4G →	+0.294	+3.169	.025	.019	3	1
UCEC	FoxM1 →	+0.323	+2.906	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

VHL by KRTAP10-11 expression — UCEC

Explore this box plot interactively →