KRTAP10-11

Across TCGA cell cohorts, KRTAP10-11 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRTAP10-11-associated genes across cancer lineages are DTHD1, DRD3, and HSFY2. Each is linked with KRTAP10-11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP10-11-to-partner and partner-to-KRTAP10-11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DTHD1 grouped by KRTAP10-11-low versus KRTAP10-11-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP10-11→partner) and Y-score (partner→KRTAP10-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DTHD1 →	+0.056	+5.087	<.001	.004	3	1
LARGE_INTESTINE	DRD3 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.052	+5.415	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	C1orf146 →	+0.028	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DTHD1 by KRTAP10-11 expression — URINARY_TRACT

Explore this box plot interactively →