KRT9

Across TCGA patient cohorts, KRT9 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT9-associated genes across cancer lineages are eIF4E, ER-alpha, and Ku80. Each is linked with KRT9 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT9-to-partner and partner-to-KRT9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KRT9-low versus KRT9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT9→partner) and Y-score (partner→KRT9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.183	+2.000	.021	.031	3	2
UCEC	ER-alpha →	-0.911	-2.321	.007	.006	3	2
UCEC	Ku80 →	+0.327	+2.335	<.001	.003	3	2
UCEC	Notch1 →	+0.289	+3.710	<.001	<.001	3	2
UCEC	ATM →	-0.559	-2.321	.002	.006	3	2
UCEC	Cyclin-B1 →	+0.772	+3.000	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eIF4E by KRT9 expression — SKCM

Explore this box plot interactively →