KRT9

Across TCGA pan-cancer cohorts, KRT9 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KRT9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRT9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT9 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

HNSC, COAD, and BRCA are the cancer types where KRT9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.193	<.001	12	view →
COAD	Female	II,III,IV	−0.533	<.001	9	view →
BRCA	Female	II,III,IV	−0.245	.001	8	view →
LUSC	Male	II,III,IV	+1.181	<.001	7	view →
BLCA	All	All	+0.830	.002	6	view →
READ	All	All	−0.392	.001	3	view →
LUAD	Male	All	+0.028	.013	3	view →
KIRP	Male	II,III,IV	+0.028	.008	3	view →
PRAD	All	All	−0.256	<.001	2	view →
CHOL	All	All	+0.038	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KRT9–HNSC

Open the HNSC breakdown →