KRT8P23

Across TCGA pan-cancer cohorts, KRT8P23 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KRT8P23’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where KRT8P23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT8P23 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

BRCA, KIRC, and COAD are the cancer types where KRT8P23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT8P23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	+0.105	<.001	8	view →
KIRC	All	II,III,IV	−0.060	<.001	5	view →
COAD	All	III,IV	+0.305	.016	3	view →
KIRP	Male	All	−0.146	.004	3	view →
CHOL	All	All	+0.114	.032	1	view →
LUAD	Male	II,III,IV	+0.099	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KRT8P23–BRCA

Open the BRCA breakdown →