KRT85

Across TCGA patient cohorts, KRT85 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT85-associated genes across cancer lineages are JNK2, MSH2, and Src_pY527. Each is linked with KRT85 in more than 3 cancer types. Because this analysis shows association rather than direction, both KRT85-to-partner and partner-to-KRT85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by KRT85-low versus KRT85-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT85→partner) and Y-score (partner→KRT85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.170	+1.884	.015	.030	3	4
UCEC	MSH2 →	-0.251	-1.662	.002	.011	3	2
UCEC	Src_pY527 →	-0.366	-1.690	.016	.042	3	2
SKCM	TAZ →	+0.227	+2.321	.004	.035	3	2
COAD	TSC1 →	-0.407	-3.161	.002	.019	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.421	+1.662	.019	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

JNK2 by KRT85 expression — UCEC

Explore this box plot interactively →