KRT85

Across TCGA cell cohorts, KRT85 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT85-associated genes across cancer lineages are CST4, AGXT2, and VCY1B. Each is linked with KRT85 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT85-to-partner and partner-to-KRT85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST4 grouped by KRT85-low versus KRT85-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT85→partner) and Y-score (partner→KRT85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CST4 →	+0.303	+3.716	<.001	.003	3	2
SKIN	AGXT2 →	+0.022	+3.103	.001	.004	3	2
SKIN	VCY1B →	+2.072	+3.334	<.001	.008	3	2
SKIN	RPS4Y2 →	+0.047	+3.376	.001	.002	3	2
LARGE_INTESTINE	CDHR4 →	+0.107	+3.299	.002	.004	3	2
URINARY_TRACT	CRYGC →	+0.200	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

CST4 by KRT85 expression — SKIN

Explore this box plot interactively →