KRT80

Across TCGA patient cohorts, KRT80 mutation is significantly associated with the RNA expression of many other genes, with 1,478 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT80-associated genes across cancer lineages are FAM21EP, RNA5SP192, and RNU2-3P. Each is linked with KRT80 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT80-to-partner and partner-to-KRT80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM21EP grouped by KRT80-low versus KRT80-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT80→partner) and Y-score (partner→KRT80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FAM21EP →	+0.184	+3.510	.001	.002	3	2
COAD	RNA5SP192 →	+0.604	+6.547	<.001	.001	3	2
COAD	RNU2-3P →	+1.483	+6.547	<.001	.001	3	2
COAD	RNU6-1208P →	+1.604	+5.357	<.001	.006	3	2
UCEC	BAG3 →	+0.659	+2.736	<.001	<.001	3	2
UCEC	PELO →	+0.483	+3.502	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,478 associations by consensus.

FAM21EP by KRT80 expression — SKCM

Explore this box plot interactively →