KRT8

Across TCGA pan-cancer cohorts, KRT8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KRT8 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KRT8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KRT8 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where KRT8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	1.000	0.784	.035	30	view →
PDAC	OS	Quartile	II,III,IV	0.722	0.308	<.001	21	view →
HNSC	OS	Tertile	All	0.583	0.804	.005	15	view →
LUAD	DFS	Quartile	II,III,IV	0.766	0.988	.010	15	view →
GBM	OS	Median	All	0.372	0.675	.002	12	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.554	.029	8	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KRT8–COAD (DFS)

Open the COAD breakdown →