KRT8

Across TCGA pan-cancer cohorts, KRT8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KRT8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KRT8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT8 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

KIRP, LUAD, and KIRC are the cancer types where KRT8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.885	<.001	11	view →
LUAD	All	III,IV	+1.589	<.001	11	view →
KIRC	Male	All	+0.748	<.001	8	view →
UCEC	All	All	+3.041	<.001	6	view →
STAD	Male	All	+2.498	<.001	6	view →
BRCA	All	III,IV	+2.438	<.001	6	view →
HNSC	Male	III,IV	+1.901	.002	3	view →
BLCA	Male	IV	+2.540	.015	2	view →
CHOL	All	All	+1.983	<.001	2	view →
PRAD	All	All	+0.512	.001	2	view →
THCA	Female	All	−0.500	<.001	2	view →
ESCA	All	All	+2.256	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KRT8–KIRP

Open the KIRP breakdown →