KRT8

Across TCGA patient cohorts, KRT8 protein abundance is significantly associated with the RNA expression of many other genes, with 12,642 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KRT8-associated genes across cancer lineages are KRT18, KRT8P45, and KRT18P11. Each is linked with KRT8 in more than 8 cancer types. Because this analysis shows association rather than direction, both KRT8-to-partner and partner-to-KRT8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KRT8 versus KRT18 in UCEC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT8→partner) and Y-score (partner→KRT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRT18 →	+1.392	+0.537	.002	<.001	2	9
OV	KRT8P45 →	+1.242	+0.532	.005	.002	3	7
BRCA	KRT18P11 →	+0.637	+0.601	<.001	<.001	3	7
BRCA	TSPAN1 →	+1.868	+0.583	<.001	<.001	3	6
OV	TSPAN3 →	+0.700	+0.685	<.001	<.001	2	7
BRCA	TMBIM6 →	+0.517	+0.710	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,642 associations by consensus.

KRT8 vs KRT18 — UCEC

Explore this scatter interactively →