KRT8

Across TCGA patient cohorts, KRT8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT8-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and PREX1. Each is linked with KRT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT8-to-partner and partner-to-KRT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KRT8-low versus KRT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT8→partner) and Y-score (partner→KRT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.235	-2.584	.020	.010	3	1
UCEC	p62 Lck ligand →	+0.270	+3.087	.039	<.001	3	1
UCEC	PREX1 →	+0.255	+2.321	.021	.034	3	1
UCEC	Annexin-1 →	+0.548	+3.321	.009	.009	3	1
UCEC	AR →	-0.356	-2.000	.017	.030	3	1
UCEC	Axl →	+0.188	+2.332	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by KRT8 expression — UCEC

Explore this box plot interactively →