KRT8

Across TCGA cell cohorts, KRT8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,512 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KRT8-associated GO terms across cancer lineages are Myofibril assembly, Sarcomere organization, and Protein localization to plasma membrane. Each is linked with KRT8 in more than 13 cancer types. Because this analysis shows association rather than direction, both KRT8-to-partner and partner-to-KRT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myofibril assembly grouped by KRT8-low versus KRT8-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT8→partner) and Y-score (partner→KRT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Myofibril assembly →	+0.173	+2.241	<.001	<.001	3	14
BREAST	Sarcomere organization →	+0.296	+3.190	<.001	<.001	3	12
OVARY	Protein localization to plasma membrane →	+0.068	+3.776	<.001	<.001	3	11
OVARY	Rho protein signal transduction →	+0.093	+2.856	<.001	<.001	3	10
BONE	Positive regulation of blood-brain barrier permeability →	+0.718	+2.151	.007	.003	3	10
LARGE_INTESTINE	Membrane raft assembly →	+0.164	+1.400	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,512 associations by consensus.

Myofibril assembly by KRT8 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →