KRT78

Across TCGA cell cohorts, KRT78 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KRT78-associated genes across cancer lineages are PYY, MCHR2, and P2RY12. Each is linked with KRT78 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT78-to-partner and partner-to-KRT78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYY grouped by KRT78-low versus KRT78-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT78→partner) and Y-score (partner→KRT78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PYY →	+0.052	+3.520	.002	.005	3	1
LARGE_INTESTINE	MCHR2 →	+0.016	+3.514	.001	.001	3	1
LARGE_INTESTINE	P2RY12 →	+0.169	+3.103	<.001	.004	3	1
LARGE_INTESTINE	OR56B1 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GOLGA8S →	+0.090	+3.817	<.001	.002	3	1
LARGE_INTESTINE	WNT8A →	+0.027	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PYY by KRT78 expression — LARGE_INTESTINE

Explore this box plot interactively →