KRT78

Across TCGA pan-cancer cohorts, KRT78 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KRT78’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRT78 RNA is repressed in tumor relative to normal tissue. In most cancer types KRT78 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where KRT78 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT78 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−5.172	<.001	12	view →
LUAD	All	II,III,IV	+0.268	<.001	8	view →
LUSC	Male	All	+1.567	<.001	7	view →
BRCA	Female	All	+0.116	.038	4	view →
KIRC	Male	All	+0.050	<.001	4	view →
COAD	All	II,III,IV	+0.037	.021	4	view →
READ	Male	All	+0.043	.022	3	view →
BLCA	Male	All	+1.137	.030	2	view →
UCEC	All	All	+0.546	.010	2	view →
PAAD	Female	All	+0.350	.019	2	view →
THCA	Female	All	+0.281	.030	2	view →
CHOL	All	All	+0.140	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KRT78–HNSC

Open the HNSC breakdown →