Across TCGA pan-cancer cohorts, KRT76 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KRT76 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KRT76 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KRT76 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where KRT76 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.430	0.629	.011	24	view →
HNSC	DFS	Tertile	IV	0.915	0.532	.001	10	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.751	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KRT76 tumor-vs-normal RNA expression · all KRT76 data types