Across TCGA pan-cancer cohorts, KRT76 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of KRT76’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRT76 RNA is repressed in tumor relative to normal tissue. In most cancer types KRT76 is over-expressed in tumor, although a few such as HNSC and STAD show the opposite, repressed pattern.

HNSC, LUSC, and STAD are the cancer types where KRT76 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT76 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−2.083	<.001	7	view →
LUSC	All	All	+0.221	<.001	4	view →
STAD	All	All	−0.074	.015	2	view →
KIRP	Male	All	−0.077	.017	1	view →
BLCA	Male	IV	+0.042	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: KRT76 RNA expression & survival · all KRT76 data types