Across TCGA patient cohorts, KRT76 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT76-associated genes across cancer lineages are MEK1, Cyclin-B1, and eIF4E. Each is linked with KRT76 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT76-to-partner and partner-to-KRT76 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT76→partner) and Y-score (partner→KRT76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.540	+2.807	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.813	+3.584	<.001	.002	3	2
UCEC	eIF4E →	+0.195	+3.183	.029	.009	3	2
UCEC	mTOR_pS2448 →	-0.216	-2.446	<.001	.018	3	2
UCEC	4E-BP1 →	+0.394	+3.489	<.001	.002	3	2
SKCM	HER3_pY1289 →	-0.078	-3.136	.030	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

KRT76 survival (RNA) · tumor vs normal (RNA) · all KRT76 data types