KRT74

Across TCGA cell cohorts, KRT74 mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT74-associated genes across cancer lineages are CCR8, LYPD2, and RGS21. Each is linked with KRT74 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT74-to-partner and partner-to-KRT74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by KRT74-low versus KRT74-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT74→partner) and Y-score (partner→KRT74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	2
SOFT_TISSUE	LYPD2 →	+0.052	+5.369	.006	.004	3	1
CNS	RGS21 →	+0.012	+4.981	<.001	.008	3	1
SKIN	RBMY1F →	+0.086	+6.022	<.001	.001	3	1
SKIN	CYLC1 →	+0.013	+5.415	<.001	.004	3	1
SKIN	FAM205C →	+0.045	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

CCR8 by KRT74 expression — SOFT_TISSUE

Explore this box plot interactively →