KRT74

Across TCGA cell cohorts, KRT74 mutation is significantly associated with the mutation status of many other genes, with 3,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT74-associated genes across cancer lineages are CELSR2, RGL2, and LAMB1. Each is linked with KRT74 in more than 4 cancer types. Because this analysis shows association rather than direction, both KRT74-to-partner and partner-to-KRT74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELSR2 grouped by KRT74-low versus KRT74-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT74→partner) and Y-score (partner→KRT74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CELSR2 →	+2.260	+3.101	.002	.002	1	5
SOFT_TISSUE	RGL2 →	+5.066	+4.502	.007	.007	1	4
BLOOD_Lymphoma	LAMB1 →	+4.014	+4.969	.008	.008	1	4
SOFT_TISSUE	LRRK1 →	+3.066	+4.369	.005	.005	1	4
SOFT_TISSUE	PCDH1 →	+5.066	+4.502	.007	.007	1	4
BLOOD_Leukemia	CELSR1 →	+2.038	+3.415	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,558 associations by consensus.

CELSR2 by KRT74 expression — BLOOD_Leukemia

Explore this box plot interactively →