Across TCGA cell cohorts, KRT73 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT73-associated genes across cancer lineages are GHR, SEMG2, and MDGA2. Each is linked with KRT73 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT73-to-partner and partner-to-KRT73 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT73→partner) and Y-score (partner→KRT73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GHR →	+0.806	+3.295	<.001	.009	3	1
LARGE_INTESTINE	SEMG2 →	+0.586	+4.141	<.001	<.001	3	1
LARGE_INTESTINE	MDGA2 →	+0.142	+3.817	<.001	.002	3	1
LARGE_INTESTINE	CLDN17 →	+0.045	+3.760	.001	<.001	3	1
LARGE_INTESTINE	TUB →	+1.852	+3.304	<.001	.008	3	1
LARGE_INTESTINE	GKN1 →	+0.051	+2.925	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

KRT73 survival (RNA) · tumor vs normal (RNA) · all KRT73 data types