KRT71

Across TCGA cell cohorts, KRT71 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT71-associated genes across cancer lineages are C1orf146, CCDC172, and VWA5B1. Each is linked with KRT71 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT71-to-partner and partner-to-KRT71 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by KRT71-low versus KRT71-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT71→partner) and Y-score (partner→KRT71) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C1orf146 →	+0.041	+4.684	<.001	.002	3	2
SKIN	CCDC172 →	+0.004	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	VWA5B1 →	+0.906	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.013	+4.078	<.001	.009	3	1
LARGE_INTESTINE	PGM3 →	+1.047	+3.067	<.001	.009	3	1
LARGE_INTESTINE	SULT6B1 →	+0.021	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

C1orf146 by KRT71 expression — SKIN

Explore this box plot interactively →