KRT6C

Across TCGA patient cohorts, KRT6C mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT6C-associated genes across cancer lineages are HER2_pY1248, STAT3_pY705, and FoxM1. Each is linked with KRT6C in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT6C-to-partner and partner-to-KRT6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2_pY1248 grouped by KRT6C-low versus KRT6C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6C→partner) and Y-score (partner→KRT6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2_pY1248 →	-0.172	-3.584	.013	.002	3	2
UCEC	STAT3_pY705 →	-0.415	-2.087	<.001	.005	3	2
UCEC	FoxM1 →	+0.207	+1.678	.037	.023	3	2
UCEC	PAI-1 →	+0.260	+1.807	.048	.025	3	2
UCEC	PCNA →	+0.284	+2.584	<.001	.001	3	2
SKCM	Lck →	-0.324	-2.459	.043	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

HER2_pY1248 by KRT6C expression — SKCM

Explore this box plot interactively →