KRT6C

Across TCGA pan-cancer cohorts, KRT6C RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KRT6C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where KRT6C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT6C is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

LUSC, COAD, and LUAD are the cancer types where KRT6C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT6C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	+4.490	<.001	8	view →
COAD	All	All	+0.094	<.001	8	view →
LUAD	All	All	+0.375	.001	3	view →
BRCA	All	III,IV	−0.445	.015	2	view →
PRAD	All	All	−0.095	.003	2	view →
THCA	All	All	+0.063	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KRT6C–LUSC

Open the LUSC breakdown →