KRT6C

Across TCGA cell cohorts, KRT6C RNA expression is significantly associated with the go_rna of many other GO terms, with 861 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible KRT6C-associated GO terms across cancer lineages are Transepithelial water transport, Cell-substrate junction organization, and Urea transmembrane transport. Each is linked with KRT6C in more than 5 cancer types. Because this analysis shows association rather than direction, both KRT6C-to-partner and partner-to-KRT6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transepithelial water transport grouped by KRT6C-low versus KRT6C-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6C→partner) and Y-score (partner→KRT6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Transepithelial water transport →	+2.175	+1.765	<.001	.001	3	6
URINARY_TRACT	Cell-substrate junction organization →	+0.151	+0.707	<.001	<.001	3	6
URINARY_TRACT	Urea transmembrane transport →	+1.495	+0.892	.003	.005	3	6
URINARY_TRACT	Calcium ion transmembrane import into cytosol →	-0.048	-0.605	<.001	.006	3	6
LUNG_NSCLC_LUSC	L-histidine transport →	+0.166	+1.230	<.001	.003	2	6
LUNG_NSCLC_LUAD	Regulation of ventricular cardiac muscle cell action potential →	+0.156	+0.053	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 861 associations by consensus.

Transepithelial water transport by KRT6C expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →