KRT6C

Across TCGA cell cohorts, KRT6C mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible KRT6C-associated genes across cancer lineages are OR12D1, OR1P1, and DAOA. Each is linked with KRT6C in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT6C-to-partner and partner-to-KRT6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D1 grouped by KRT6C-low versus KRT6C-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6C→partner) and Y-score (partner→KRT6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR12D1 →	+0.016	+5.000	<.001	.006	3	2
PANCREAS	OR1P1 →	+0.032	+5.000	<.001	.006	3	2
STOMACH	DAOA →	+0.060	+5.285	<.001	.003	3	2
PANCREAS	OR10AG1 →	+0.019	+5.000	<.001	.006	3	1
PANCREAS	OR2W1 →	+0.020	+5.614	<.001	.002	3	1
PANCREAS	TAS2R39 →	+0.019	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

OR12D1 by KRT6C expression — PANCREAS

Explore this box plot interactively →