Across TCGA pan-cancer cohorts, KRT6B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KRT6B data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRT6B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KRT6B expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where KRT6B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.945	0.770	.003	71	view →
PDAC	OS	Median	II,III,IV	0.433	0.610	.006	43	view →
UCEC	OS	Tertile	All	1.000	0.769	.026	8	view →
LSCC	DFS	Median	All	0.975	0.892	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KRT6B tumor-vs-normal RNA expression · all KRT6B data types