Across TCGA patient cohorts, KRT6B mutation is significantly associated with the RNA expression of many other genes, with 2,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT6B-associated genes across cancer lineages are PBK, TIPIN, and MCM6. Each is linked with KRT6B in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT6B-to-partner and partner-to-KRT6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6B→partner) and Y-score (partner→KRT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.810	+1.958	<.001	<.001	3	3
UCEC	TIPIN →	+0.506	+2.243	<.001	<.001	3	3
UCEC	MCM6 →	+0.451	+2.321	.006	.005	3	3
UCEC	RBFA →	+0.411	+2.202	<.001	.001	3	3
UCEC	PARP2 →	+0.414	+2.119	<.001	<.001	3	3
UCEC	CCL4 →	+0.662	+1.721	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,250 associations by consensus.

Exploration

KRT6B survival (RNA) · tumor vs normal (RNA) · all KRT6B data types