KRT6B

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KRT6B mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT6B-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and XBP1. Each is linked with KRT6B in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT6B-to-partner and partner-to-KRT6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6B→partner) and Y-score (partner→KRT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeIF4E →+0.189+3.598.006.00132
UCECmTOR_pS2448 →-0.105-1.395.031.04332
UCECXBP1 →-0.124-1.415.007.04332
UCECCaspase-7-cleavedD198 →+0.511+1.906.008.01432
UCECCaspase-8 →-0.248-4.060.002<.00132
SKCMC-Raf →+0.180+2.824.006.03432
Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

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