Across TCGA cell cohorts, KRT6B mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT6B-associated genes across cancer lineages are LHCGR, HSD3B2, and KRTAP10-1. Each is linked with KRT6B in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT6B-to-partner and partner-to-KRT6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6B→partner) and Y-score (partner→KRT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LHCGR →	+0.081	+3.836	.008	.004	3	2
OESOPHAGUS	HSD3B2 →	+0.083	+4.108	<.001	.005	3	2
OESOPHAGUS	KRTAP10-1 →	+0.070	+4.115	<.001	.001	3	2
LARGE_INTESTINE	CLDN17 →	+0.051	+3.345	<.001	.007	3	2
LARGE_INTESTINE	OR9A2 →	+0.018	+3.347	<.001	.005	3	2
STOMACH	KRT28 →	+0.011	+4.432	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

KRT6B survival (RNA) · tumor vs normal (RNA) · all KRT6B data types