KRT6A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KRT6A mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT6A-associated genes across cancer lineages are INPP4B, eEF2, and A-Raf_pS299. Each is linked with KRT6A in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT6A-to-partner and partner-to-KRT6A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT6A→partner) and Y-score (partner→KRT6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECINPP4B →-0.355-2.807.003.00333
UCECeEF2 →+0.337+2.584.012.01032
UCECA-Raf_pS299 →-0.191-2.700<.001.00632
UCECACC1 →+0.272+1.415.046.04632
UCECATM →-0.697-3.794<.001<.00132
UCECCaspase-8 →-0.268-3.880.004<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Exploration