KRT34

Across TCGA patient cohorts, KRT34 mutation is significantly associated with the RNA expression of many other genes, with 1,891 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT34-associated genes across cancer lineages are RRM1-AS1, SNORA10B, and HAUS1. Each is linked with KRT34 in more than 3 cancer types. Because this analysis shows association rather than direction, both KRT34-to-partner and partner-to-KRT34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RRM1-AS1 grouped by KRT34-low versus KRT34-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT34→partner) and Y-score (partner→KRT34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RRM1-AS1 →	+0.123	+2.091	.001	.001	3	4
LGG	SNORA10B →	+0.395	+3.742	<.001	.008	3	3
UCEC	HAUS1 →	+0.500	+1.695	.003	.007	3	3
UCEC	SNRPD1 →	+0.442	+2.010	.002	.001	3	3
UCEC	TYMS →	+0.772	+2.329	.001	.003	2	4
UCEC	TIMM22 →	+0.490	+2.928	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,891 associations by consensus.

RRM1-AS1 by KRT34 expression — SKCM

Explore this box plot interactively →