KRT34

Across TCGA cell cohorts, KRT34 mutation is significantly associated with the RNA expression of many other genes, with 468 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT34-associated genes across cancer lineages are PES1, PATZ1, and ANKRD54. Each is linked with KRT34 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT34-to-partner and partner-to-KRT34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PES1 grouped by KRT34-low versus KRT34-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT34→partner) and Y-score (partner→KRT34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PES1 →	+0.483	+3.537	.009	.001	3	1
LARGE_INTESTINE	PATZ1 →	+0.565	+3.364	.004	.002	3	1
LARGE_INTESTINE	ANKRD54 →	+0.560	+3.067	<.001	.009	3	1
LARGE_INTESTINE	CCDC134 →	+0.677	+3.364	.007	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.596	+3.364	.003	.002	3	1
LARGE_INTESTINE	BCKDK →	+0.677	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 468 associations by consensus.

PES1 by KRT34 expression — LARGE_INTESTINE

Explore this box plot interactively →