KRT33A

Across TCGA patient cohorts, KRT33A mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT33A-associated genes across cancer lineages are A-Raf_pS299, AMPK_pT172, and 4E-BP1. Each is linked with KRT33A in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT33A-to-partner and partner-to-KRT33A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by KRT33A-low versus KRT33A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT33A→partner) and Y-score (partner→KRT33A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.097	-1.362	.021	.037	3	2
UCEC	AMPK_pT172 →	+0.344	+1.375	.017	.024	3	2
UCEC	4E-BP1 →	+0.265	+1.936	.005	.008	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.584	.009	.010	3	1
UCEC	FOXO3a →	+0.107	+1.598	.002	.040	3	1
UCEC	INPP4B →	-0.236	-2.584	.038	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

A-Raf_pS299 by KRT33A expression — UCEC

Explore this box plot interactively →