KRT33A

Across TCGA pan-cancer cohorts, KRT33A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KRT33A data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KRT33A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KRT33A expression acts as an unfavorable survival marker, although some lineages such as CESC and STAD show a favorable association.

CESC, STAD, and LGG are the cancer types where KRT33A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	All	0.907	0.739	<.001	40	view →
STAD	OS	Quartile	IV	0.664	0.223	.015	32	view →
LGG	OS	Median	All	0.878	0.748	<.001	31	view →
PAAD	DFS	Tertile	All	0.540	0.227	.001	30	view →
MESO	DFS	Quartile	All	0.250	0.395	.018	27	view →
LIHC	OS	Tertile	III,IV	0.059	0.738	<.001	27	view →
HNSC	DFS	Quartile	IV	0.741	0.327	.003	25	view →
KIRP	OS	Quartile	II,III,IV	0.189	0.790	.004	24	view →
KIRC	DFS	Median	All	0.505	0.721	.008	20	view →
SKCM	OS	Tertile	All	0.786	0.894	.009	15	view →
KICH	OS	Tertile	All	0.831	0.992	.014	9	view →
ESCA	OS	Quartile	II,III,IV	0.532	0.279	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KRT33A–CESC (DFS)

Open the CESC breakdown →