KRT32

Across TCGA patient cohorts, KRT32 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT32-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and p90 RSK. Each is linked with KRT32 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT32-to-partner and partner-to-KRT32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by KRT32-low versus KRT32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT32→partner) and Y-score (partner→KRT32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.099	-1.571	.012	.036	3	2
UCEC	EGFR_pY1068 →	-0.234	-2.584	.017	.010	3	2
SKCM	p90 RSK →	+0.230	+3.169	.045	.019	3	1
UCEC	EGFR →	-0.223	-3.295	<.001	.009	3	1
UCEC	MSH6 →	-0.415	-2.459	.001	.018	3	1
UCEC	p62 Lck ligand →	+0.296	+2.009	.020	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

14-3-3_beta by KRT32 expression — UCEC

Explore this box plot interactively →