Across TCGA patient cohorts, KRT3 mutation is significantly associated with the RNA expression of many other genes, with 3,107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT3-associated genes across cancer lineages are MTHFD1, E2F1, and MRPS15. Each is linked with KRT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT3-to-partner and partner-to-KRT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT3→partner) and Y-score (partner→KRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTHFD1 →	+0.493	+1.947	<.001	.002	3	3
UCEC	E2F1 →	+0.836	+2.711	<.001	<.001	3	3
UCEC	MRPS15 →	+0.326	+2.742	.004	.002	3	3
UCEC	ZWINT →	+0.770	+2.888	<.001	<.001	3	3
UCEC	YARS1 →	+0.546	+2.053	<.001	<.001	3	3
SKCM	RPP30 →	+0.359	+1.970	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,107 associations by consensus.

Exploration

KRT3 survival (RNA) · tumor vs normal (RNA) · all KRT3 data types