Across TCGA pan-cancer cohorts, KRT3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KRT3 data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KRT3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRT3 expression acts as an unfavorable survival marker, although some lineages such as LGG and PRAD show a favorable association.

KIRC, COAD, and LIHC are the cancer types where KRT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.524	0.685	.007	76	view →
COAD	DFS	Median	All	0.683	0.835	<.001	59	view →
LIHC	OS	Tertile	All	0.545	0.709	.009	36	view →
STAD	OS	Tertile	III,IV	0.378	0.626	.002	36	view →
BRCA	OS	Median	IV	0.344	0.844	.001	36	view →
BLCA	OS	Median	IV	0.229	0.635	.002	21	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
LGG	DFS	Median	All	0.881	0.788	.011	15	view →
PRAD	DFS	Tertile	All	0.993	0.917	.002	12	view →
KIRP	DFS	Median	II,III,IV	0.352	0.840	.034	10	view →
UVM	DFS	Tertile	III,IV	0.071	0.636	<.001	9	view →
MESO	DFS	Tertile	III,IV	0.759	0.288	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: KRT3 tumor-vs-normal RNA expression · all KRT3 data types