Across TCGA patient cohorts, KRT3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT3-associated genes across cancer lineages are MEK1, C-Raf, and NDRG1_pT346. Each is linked with KRT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT3-to-partner and partner-to-KRT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT3→partner) and Y-score (partner→KRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.439	+2.459	<.001	<.001	3	3
COAD	C-Raf →	+0.187	+2.815	.019	.036	3	3
SKCM	NDRG1_pT346 →	-0.551	-1.906	.036	.016	3	2
SKCM	Rab25 →	-0.206	-3.153	.042	.018	3	2
SKCM	Syk →	+0.438	+2.321	.026	.033	3	2
COAD	p62 Lck ligand →	+0.525	+2.815	.013	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

KRT3 survival (RNA) · tumor vs normal (RNA) · all KRT3 data types