Across TCGA cell cohorts, KRT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 559 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KRT3-associated GO terms across cancer lineages are Regulation of ruffle assembly, Negative regulation of syncytium formation by plasma membrane fusion, and G protein-coupled purinergic nucleotide receptor signaling pathway. Each is linked with KRT3 in more than 4 cancer types. Because this analysis shows association rather than direction, both KRT3-to-partner and partner-to-KRT3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT3→partner) and Y-score (partner→KRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of ruffle assembly →	+0.121	+0.273	<.001	.008	3	4
LUNG_NSCLC_LUAD	Negative regulation of syncytium formation by plasma membrane fusion →	+0.052	+0.231	.008	.005	2	5
BREAST	G protein-coupled purinergic nucleotide receptor signaling pathway →	+0.971	+0.257	.004	.006	3	4
LUNG_NSCLC_LUAD	Plasma membrane raft organization →	+0.125	+0.377	<.001	.004	3	4
SOFT_TISSUE	Negative regulation of canonical NF-kappaB signal transduction →	+0.062	+0.015	<.001	<.001	2	5
LARGE_INTESTINE	Regulation of non-canonical NF-kappaB signal transduction →	+0.056	+0.114	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 559 associations by consensus.

Exploration

KRT3 survival (RNA) · tumor vs normal (RNA) · all KRT3 data types