Across TCGA cell cohorts, KRT3 mutation is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible KRT3-associated genes across cancer lineages are SPATA19, ZNF705A, and PHB2. Each is linked with KRT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT3-to-partner and partner-to-KRT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT3→partner) and Y-score (partner→KRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPATA19 →	+0.422	+4.472	<.001	.004	3	3
OESOPHAGUS	ZNF705A →	+0.012	+2.421	.003	.001	3	2
OESOPHAGUS	PHB2 →	+0.466	+3.169	<.001	.005	3	2
STOMACH	TMEM235 →	+0.008	+3.209	<.001	.007	3	2
CNS	LCE2B →	+0.060	+5.357	<.001	.001	3	2
CNS	LCE2D →	+0.040	+5.357	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

Exploration

KRT3 survival (RNA) · tumor vs normal (RNA) · all KRT3 data types