KRT28

Across TCGA patient cohorts, KRT28 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT28-associated genes across cancer lineages are ATM, EGFR_pY1068, and ERK2. Each is linked with KRT28 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT28-to-partner and partner-to-KRT28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KRT28-low versus KRT28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT28→partner) and Y-score (partner→KRT28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.414	-1.700	.017	.042	3	3
UCEC	EGFR_pY1068 →	-0.257	-2.000	.007	.030	3	2
UCEC	ERK2 →	+0.175	+2.321	.017	.033	3	2
UCEC	Shc_pY317 →	-0.162	-2.087	.005	.005	3	2
UCEC	ASNS →	+0.462	+1.807	<.001	.025	3	2
UCEC	4E-BP1 →	+0.326	+3.489	.001	.002	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by KRT28 expression — UCEC

Explore this box plot interactively →