KRT28

Across TCGA cell cohorts, KRT28 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRT28-associated genes across cancer lineages are SLC10A2, CALHM4, and PROP1. Each is linked with KRT28 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT28-to-partner and partner-to-KRT28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC10A2 grouped by KRT28-low versus KRT28-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT28→partner) and Y-score (partner→KRT28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC10A2 →	+0.006	+6.022	<.001	.001	3	1
BLOOD_Leukemia	CALHM4 →	+0.030	+4.269	<.001	.002	3	1
BLOOD_Leukemia	PROP1 →	+0.025	+3.874	<.001	.005	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	POU1F1 →	+0.159	+3.921	.007	.006	3	1
LUNG_NSCLC_LUAD	C1QC →	+0.022	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SLC10A2 by KRT28 expression — SKIN

Explore this box plot interactively →