Across TCGA pan-cancer cohorts, KRT26 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KRT26 data layer compared with 15 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KRT26 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KRT26 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SKCM, and SCLC are the cancer types where KRT26 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.632	.017	12	view →
SKCM	OS	Median	III,IV	0.518	0.847	<.001	7	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
HNSC	OS	Median	All	0.228	0.661	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KRT26 tumor-vs-normal RNA expression · all KRT26 data types