Across TCGA patient cohorts, KRT25 mutation is significantly associated with the RNA expression of many other genes, with 1,695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT25-associated genes across cancer lineages are FBXW2, GOLGA1, and CASP3. Each is linked with KRT25 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT25-to-partner and partner-to-KRT25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT25→partner) and Y-score (partner→KRT25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXW2 →	+0.377	+1.818	.003	.002	3	3
UCEC	GOLGA1 →	+0.322	+2.439	.005	.001	3	3
UCEC	CASP3 →	+0.377	+2.194	.008	.001	3	3
SKCM	PDZD8 →	+0.745	+3.195	<.001	.009	3	3
SKCM	ONECUT1 →	+0.627	+3.459	.001	.005	3	3
SKCM	PDE12 →	+0.503	+3.613	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,695 associations by consensus.

Exploration

KRT25 survival (RNA) · tumor vs normal (RNA) · all KRT25 data types