Across TCGA pan-cancer cohorts, KRT25 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated KRT25 data layer compared with 4 for mutation status.
The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KRT25 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRT25 expression acts as an unfavorable survival marker, although some lineages such as THYM and UCS show a favorable association.
SKCM, KIRC, and KICH are the cancer types where KRT25 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.