Across TCGA cell cohorts, KRT25 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KRT25-associated genes across cancer lineages are SPINT4, OR4F4, and IL9. Each is linked with KRT25 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT25-to-partner and partner-to-KRT25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT25→partner) and Y-score (partner→KRT25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINT4 →	+0.058	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.006	+4.887	.009	.009	3	1
BLOOD_Leukemia	IL9 →	+0.148	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SSX7 →	+0.053	+4.539	<.001	.007	3	1
CNS	S100G →	+0.272	+5.321	<.001	.005	3	1
CNS	GUCA2B →	+0.050	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

KRT25 survival (RNA) · tumor vs normal (RNA) · all KRT25 data types