KRT23

Across TCGA patient cohorts, KRT23 mutation is significantly associated with the RNA expression of many other genes, with 1,709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT23-associated genes across cancer lineages are RNA5SP411, BNIP3P19, and ACAD8. Each is linked with KRT23 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT23-to-partner and partner-to-KRT23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by KRT23-low versus KRT23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT23→partner) and Y-score (partner→KRT23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.053	+1.656	<.001	.007	3	3
LIHC	BNIP3P19 →	+0.105	+5.108	.009	.008	3	2
UCEC	ACAD8 →	+0.412	+2.423	.002	.001	3	2
UCEC	SLC25A4 →	+0.545	+1.936	<.001	.003	3	2
UCEC	NEIL2 →	+0.474	+1.925	.006	.005	3	2
UCEC	VPS26C →	+0.444	+2.922	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,709 associations by consensus.

RNA5SP411 by KRT23 expression — UCEC

Explore this box plot interactively →