KRT23

Across TCGA patient cohorts, KRT23 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT23-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and A-Raf_pS299. Each is linked with KRT23 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT23-to-partner and partner-to-KRT23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by KRT23-low versus KRT23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT23→partner) and Y-score (partner→KRT23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.231	-2.780	.014	.003	3	2
UCEC	EGFR_pY1068 →	-0.222	-2.169	.018	.003	3	1
UCEC	A-Raf_pS299 →	-0.097	-2.222	.030	.010	3	1
UCEC	MEK1 →	+0.272	+1.765	.047	.014	3	1
UCEC	MSH2 →	-0.272	-3.433	.001	.005	3	1
UCEC	MSH6 →	-0.359	-2.321	.003	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-8 by KRT23 expression — UCEC

Explore this box plot interactively →